Indinavir crystalluria

Struvite Crystalluria: Three Cases

The following cases demonstrate the importance of evaluating the total clinical picture and explore how preparing dry-mount urine sediment cytology can maximize the potential of in-house urinalysis. Dry-mount cytology is a quick and relatively easy technique useful not only for evaluating conditions such as urinary tract infection (UTI) or neoplasia but when seeking a pathologist’s second opini...

Crystalluria in a dog

Mechanism of indinavir-induced hyperbilirubinemia.

Indinavir is a viral protease inhibitor used for the treatment of HIV infection. Unconjugated hyperbilirubinemia develops in up to 25% of patients receiving indinavir, prompting drug discontinuation and further clinical evaluation in some instances. We postulated that this side-effect is due to indinavir-mediated impairment of bilirubin UDP-glucuronosyltransferase (UGT) activity and would be mo...

The use of pharmacokinetically guided indinavir dose reductions in the management of indinavir-associated renal toxicity.

OBJECTIVES Indinavir is associated with nephrotoxicity. Therapeutic drug monitoring of indinavir improves clinical outcome, but there is little data regarding therapeutic drug monitoring for patients with established indinavir-associated renal impairment. We prospectively studied the use of therapeutic drug monitoring in patients with virological success but established nephrotoxicity on an ind...

Amoxycillin, a rare but possible cause of crystalluria.

Crystalluria caused by amoxycillin is a rare event that may be asymptomatic or may have severe renal implications. In January 2002 a urine sample from a 64-year-old woman which contained a large amount of unusual crystals was referred to us. Macroscopically the urine was normal. By dipstick, pH was 5.5, relative density 1.030, and albumin" haemoglobin and leukocyte esterase were negative. Howev...